Hog Tuber – Polyporus umbellatus 12-21-2019

It is used as a diuretic and a stress reducer. Tests have shown strong anti-tumor, anti-inflammatory, and anti-viral properties.

Polyporus umbellatus polysaccharide (PUPS) has been identified as the major bioactive component in the mushroom Polyporus umbellatus that has immuno-enhancing, anti-tumor, anti-inflammatory, and hepatoprotective activities. Both PUPS capsule and injection are Chinese Food and Drug Administration (SFDA) approved drugs, which have been used alone or in combination with a variety of clinical drugs for treating Hepatitis B, lung and liver cancers in China since 1990. https://www.ncbi.nlm.nih.gov/m/pubmed/31030753/?i=5&from=Polypo...]

Breast cancer (BC) is the foremost cause of cancer-related mortality in women worldwide. Polyporus umbellatus is a polysaccharide preparation of the Chinese traditional herb medicine, which has been explored as an inhibitory compound in suppressing many cancers. In our study, western blot, RT-PCR, immunochemical assay, immunofluorescence as well as flow cytometry were performed in vitro or in vivo to determine the effects of Polyporus umbellatus on the progression of human laryngeal cancer.

First, the breast cancer cell growth, invasion, and migration were inhibited, as well as the tumor volume in nude mice was down-regulated for Polyporus umbellatus use. Additionally, our data also showed that Polyporus umbellatus suppressed breast cancer cells proliferation, which was linked with the down-regulation of AKT activation by Polyporus umbellatus treatment. Mdm was inactivated while p53 was stimulated for Polyporus umbellatus administration, displaying an inhibitory role in tumor growth.
Furthermore, Polyporus umbellatus could up-regulate breast cancer cells in G0/G1 phase during the cell cycle, and at the same time reducing cells in the S phase. In conclusion, our data indicated that Polyporus umbellatus had a potential role in controlling human breast cancer through inhibiting tumor cell proliferation, inducing apoptosis regulated by AKT, which might provide a therapeutic strategy for breast cancer suppression in the future. https://www.ncbi.nlm.nih.gov/pubmed/27447121 Copyright © 2016. Published by Elsevier Masson SAS.

https://www.researchgate.net/publication/49735647_Inhibition_of_Uri...
Furthermore, the GSTPi and NQO1 mRNA upregulated level in the low-dose group (SPUE 50 mg/kg) was at maximum. In brief, SPUE and PPS are highly effective in inhibiting bladder carcinogenesis in rats, which may be associated with the upregulation of GSTPi and NQO1 in the bladder.