Schizophyllum Commune – 1-16-2020
The cosmopolitan wood-loving mushroom, Schizophyllum commune, is used as a traditional food throughout Southeast Asia and India. Researchers have intensively studied a (1→3)-β-D-glucan from the mycelium extract, Schizophyllan (SPG) since the 1970s, and today it is used as a biological response modifier (BRM) in combination with chemo- and radiation therapy, especially for cervical and gastric cancers. Based on an abundance of preliminary evidence showing binding of its (1→3)-β-D-glucan to dectin-1 receptors of macrophages and other cells, activation of a T-cell cascade with subsequent increased production of cytokines, such as interleukins and tumor necrosis factor (TNF-α), reduction of tumor size and growth, increased survival of tumor-bearing animals, and a few controlled human trials of varying methodologies and quality, it continues to be used in clinical practice. Larger, well-designed clinical trials are needed to secure its place in modern medical practice in other countries. Fundamental questions such as whether the oral application is effective, determination of proper dose, frequency and length of administration, and whether SPG is effective with other types of cancer still need to be answered.
https://www.researchgate.net/publication/247854849_The_Chemistry_Nu...
Its polysaccharide SPG demonstrates potent anticancer effects in clinical practice. Schizophyllum commune has been shown with certain anticancer applications [13,15]. This review highlights bioactivities of mushroom polysaccharides, their structure-activity relationship and the possible mechanisms of action, as well as their potential as immunoceuticals and anti-cancer agents. Schizophyllan (SPG) is a mushroom polysaccharide isolated from Schizophyllum commune Fr (Schizophyllaceae), which has also been clinically used for the treatment of cancer in Japan [26,32]. Komatsu et al. discovered SPG and demonstrated that it displayed host-mediated anti-tumor activity against Sarcoma 180 [33]. SPG was shown to stimulate the immune system and activate NK cells, spleen cells, lymphoid cells as well as bone marrow cells and enhance the production of anti-tumor/ immunostimulatory cytokines such as interleukins 1, 2 and 3 [32,34]. Clinical studies indicated that SPG used in immunochemotherapy in combination with chemotherapeutic agents (tegafur or mitomycin and 5-fluorouracil) significantly prolonged the survival of patients with stage II cervical cancer, compared to chemotherapy without SPG [32].
http://nutraceuticals.imedpub.com/bioactive-mushroom-polysaccharide...
Split Gill, split-fold – Schizophyllum commune
This mushroom has anti-tumor and immune-enhancing effects, in China and Japan; it is used in conjunction with chemo and radiation therapy to treat cancer. It is found worldwide. Apparently inhibits chromosomal damage caused by chemotherapy and radiation treatments.
Tags:
Need help? Visit our Support Group for help from our friendly Admins and members!
Visit The Temple
on Facebook:
Posted by Atrayo on April 17, 2024 at 10:26am 0 Comments 1 Like
Posted by Atrayo on April 14, 2024 at 7:54am 0 Comments 1 Like
Posted by Atrayo on April 6, 2024 at 1:51pm 0 Comments 1 Like
Posted by Ghillie Dhu on March 2, 2024 at 5:06am 4 Comments 0 Likes
Posted by Atrayo on February 22, 2024 at 12:54am 0 Comments 1 Like
Posted by Atrayo on February 14, 2024 at 6:57pm 0 Comments 1 Like
Posted by Bill Walker on February 1, 2024 at 8:15pm 1 Comment 1 Like
Posted by Sky a.k.a. JD Aeon on January 7, 2024 at 4:43am 1 Comment 5 Likes
Posted by Atrayo on December 29, 2023 at 1:04pm 0 Comments 1 Like
Posted by Kitt on December 14, 2023 at 8:55pm 2 Comments 4 Likes
Posted by Atrayo on November 29, 2023 at 11:21pm 0 Comments 2 Likes
Posted by 06iiris on October 13, 2023 at 8:30am 0 Comments 1 Like
Posted by 06iiris on October 13, 2023 at 7:00am 0 Comments 0 Likes
Posted by 06iiris on October 12, 2023 at 3:30pm 0 Comments 0 Likes
Posted by 06iiris on October 12, 2023 at 6:00am 0 Comments 0 Likes
Posted by 06iiris on October 12, 2023 at 5:30am 0 Comments 0 Likes
Posted by 06iiris on October 11, 2023 at 1:00pm 0 Comments 0 Likes
Posted by 06iiris on October 11, 2023 at 8:30am 0 Comments 0 Likes
Posted by 06iiris on October 9, 2023 at 7:30am 0 Comments 0 Likes
Posted by 06iiris on October 5, 2023 at 1:00pm 0 Comments 0 Likes
Added by Imelda James 0 Comments 0 Likes
Added by Imelda James 0 Comments 0 Likes
Added by Bryan_Thoth 0 Comments 0 Likes
© 2024 Created by Bryan Powered by